The process of Westward Expansion in the United States encountered significant conflicts between Native American tribes and the incoming settlers. As settlers moved west, they often encroached upon Native American territories, leading to tensions and clashes. The policies and actions of the U.S. government further exacerbated these conflicts.

One key event during this period was the enactment of the Indian Removal Act in 1830. This law, signed by President Andrew Jackson, authorized the forced removal of Native American tribes from their ancestral lands in the southeastern United States to areas designated as Indian Territory, located in present-day Oklahoma. The relocation process, often referred to as the Trail of Tears, resulted in the displacement and suffering of thousands of Native Americans. This forced migration led to the deaths of thousands due to disease, exposure, and lack of provisions.

Another significant conflict between Native Americans and settlers was the Battle of Little Bighorn in 1876. This battle, also known as Custer's Last Stand, occurred between the U.S. Army's 7th Cavalry Regiment and a coalition of Native American tribes, primarily the Lakota Sioux and Cheyenne. Led by Sitting Bull and Crazy Horse, the Native American forces successfully defeated Lieutenant Colonel George Custer and his troops.

These confrontations highlighted the resistance of Native American tribes against the encroachment on their lands and their efforts to protect their way of life. The forced removals and violent clashes had a profound impact on the indigenous peoples and their communities, leading to lasting consequences that continue to shape Native American history and the relationship with the United States.