In Flexbox, aligning both the main and cross axes of flex containers and items plays a crucial role in creating visually appealing layouts. Let's dive into some key properties that can help achieve alignment.

1. align-items: This property allows you to align flex items along the cross axis of the container. It takes values like flex-start, flex-end, center, baseline, and stretch. For example, setting align-items: center; will vertically center the items in the container.

2. align-content: If you have a flex container with multiple lines of flex items, this property allows you to control their alignment along the cross axis. Values such as flex-start, flex-end, center, space-between, space-around, and stretch can be used to adjust the alignment as needed.

3. align-self: This property lets you override the alignment set by the container for a specific flex item. It accepts the same values as align-items, allowing you to customize the alignment for individual items.

By using these properties effectively, you can achieve precise alignment within your Flexbox layout.