Manifest Destiny had significant consequences for Native American tribes throughout the United States. As the country expanded westward, Native Americans were forcibly displaced from their ancestral lands, resulting in a devastating impact on their communities and way of life.

One notable example of this displacement is the Trail of Tears. In the 1830s, the Indian Removal Act was passed, leading to the forced relocation of thousands of Native Americans, primarily from the Southeastern United States. The Cherokee Nation, in particular, was severely affected, as they were forcibly removed from their lands and forced to march westward to present-day Oklahoma. The journey was treacherous, with many Native Americans dying from exposure, hunger, and disease.

Another significant conflict that arose between settlers and indigenous people was the Battle of Little Bighorn. In 1876, tensions between the U.S. government and Native American tribes, such as the Lakota Sioux and Northern Cheyenne, reached a boiling point. The tribes fought against U.S. forces in an attempt to protect their lands and way of life. Although the Native American tribes achieved a significant victory in this battle, it ultimately fueled further aggression and displacement by the U.S. government.

The impact of Manifest Destiny on Native American tribes cannot be understated. Not only did it lead to the loss of ancestral lands and forced relocations, but it also resulted in the destruction of cultural traditions and the detrimental effects of assimilation policies. Native American tribes continue to face the consequences of this displacement and the long-lasting social, economic, and psychological impact it has had on their communities.